H2N2V1, Main, Exploration, bibRecord, 000F93

A Live Attenuated H7N7 Candidate Vaccine Virus Induces Neutralizing Antibody That Confers Protection from Challenge in Mice, Ferrets, and Monkeys

Identifieur interne : 000F93 ( Main/Exploration ); précédent : 000F92; suivant : 000F94

A Live Attenuated H7N7 Candidate Vaccine Virus Induces Neutralizing Antibody That Confers Protection from Challenge in Mice, Ferrets, and Monkeys

Auteurs : Ji-Young Min [États-Unis] ; Leatrice Vogel [États-Unis] ; Yumiko Matsuoka [États-Unis] ; BIN LU [États-Unis] ; David Swayne [États-Unis] ; HONG JIN [États-Unis] ; George Kemble [États-Unis] ; Kanta Subbarao [États-Unis]

Source :

Journal of virology [ 0022-538X ] ; 2010.

RBID : Pascal:10-0511493

Descripteurs français

Pascal (Inist)
- Souris, Singe, Souche atténuée, Vaccin, Anticorps neutralisant.
Wicri :
- topic : Singe, Vaccin.

English descriptors

KwdEn :
- Attenuated strain, Monkey, Mouse, Neutralizing antibody, Vaccine.

Abstract

A live attenuated H7N7 candidate vaccine virus was generated by reverse genetics using the modified hemagglutinin (HA) and neuraminidase (NA) genes of highly pathogenic (HP) A/Netherlands/219/03 (NL/03) (H7N7) wild-type (wt) virus and the six internal protein genes of the cold-adapted (ca) A/Ann Arbor/6/60 ca (AA ca) (H2N2) virus. The reassortant H7N7 NL/03 ca vaccine virus was temperature sensitive and attenuated in mice, ferrets, and African green monkeys (AGMs). Intranasal (i.n.) administration of a single dose of the H7N7 NL/03 ca vaccine virus fully protected mice from lethal challenge with homologous and heterologous H7 viruses from Eurasian and North American lineages. Two doses of the H7N7 NL/03 ca vaccine induced neutralizing antibodies in serum and provided complete protection from pulmonary replication of homologous and heterologous wild-type H7 challenge viruses in mice and ferrets. One dose of the H7N7 NL/03 ca vaccine elicited an antibody response in one of three AGMs that was completely protected from pulmonary replication of the homologous wild-type H7 challenge virus. The contribution of CD8⁺ and/or CD4⁺ T cells to the vaccine-induced protection of mice was evaluated by T-cell depletion; T lymphocytes were not essential for the vaccine-induced protection from lethal challenge with H7 wt viruses. Additionally, passively transferred neutralizing antibody induced by the H7N7 NL/03 ca virus protected mice from lethality following challenge with H7 wt viruses. The safety, immunogenicity, and efficacy of the H7N7 NL/03 ca vaccine virus in mice, ferrets, and AGMs support the evaluation of this vaccine virus in phase I clinical trials.

Affiliations:

États-Unis

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000016
to stream PascalFrancis, to step Curation: 000058
to stream PascalFrancis, to step Checkpoint: 000023
to stream Main, to step Merge: 001001
to stream Main, to step Curation: 000F93

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A Live Attenuated H7N7 Candidate Vaccine Virus Induces Neutralizing Antibody That Confers Protection from Challenge in Mice, Ferrets, and Monkeys</title>
<author><name sortKey="Min, Ji Young" sort="Min, Ji Young" uniqKey="Min J" first="Ji-Young" last="Min">Ji-Young Min</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Matsuoka, Yumiko" sort="Matsuoka, Yumiko" uniqKey="Matsuoka Y" first="Yumiko" last="Matsuoka">Yumiko Matsuoka</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bin Lu" sort="Bin Lu" uniqKey="Bin Lu" last="Bin Lu">BIN LU</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Swayne, David" sort="Swayne, David" uniqKey="Swayne D" first="David" last="Swayne">David Swayne</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Southeast Poultry Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture</s1>
<s2>Athens, Georgia 30605</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Athens, Georgia 30605</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hong Jin" sort="Hong Jin" uniqKey="Hong Jin" last="Hong Jin">HONG JIN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0511493</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0511493 INIST</idno>
<idno type="RBID">Pascal:10-0511493</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000016</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000058</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000023</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000023</idno>
<idno type="wicri:doubleKey">0022-538X:2010:Min J:a:live:attenuated</idno>
<idno type="wicri:Area/Main/Merge">001001</idno>
<idno type="wicri:Area/Main/Curation">000F93</idno>
<idno type="wicri:Area/Main/Exploration">000F93</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A Live Attenuated H7N7 Candidate Vaccine Virus Induces Neutralizing Antibody That Confers Protection from Challenge in Mice, Ferrets, and Monkeys</title>
<author><name sortKey="Min, Ji Young" sort="Min, Ji Young" uniqKey="Min J" first="Ji-Young" last="Min">Ji-Young Min</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Matsuoka, Yumiko" sort="Matsuoka, Yumiko" uniqKey="Matsuoka Y" first="Yumiko" last="Matsuoka">Yumiko Matsuoka</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bin Lu" sort="Bin Lu" uniqKey="Bin Lu" last="Bin Lu">BIN LU</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Swayne, David" sort="Swayne, David" uniqKey="Swayne D" first="David" last="Swayne">David Swayne</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Southeast Poultry Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture</s1>
<s2>Athens, Georgia 30605</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Athens, Georgia 30605</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hong Jin" sort="Hong Jin" uniqKey="Hong Jin" last="Hong Jin">HONG JIN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Attenuated strain</term>
<term>Monkey</term>
<term>Mouse</term>
<term>Neutralizing antibody</term>
<term>Vaccine</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Souris</term>
<term>Singe</term>
<term>Souche atténuée</term>
<term>Vaccin</term>
<term>Anticorps neutralisant</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Singe</term>
<term>Vaccin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A live attenuated H7N7 candidate vaccine virus was generated by reverse genetics using the modified hemagglutinin (HA) and neuraminidase (NA) genes of highly pathogenic (HP) A/Netherlands/219/03 (NL/03) (H7N7) wild-type (wt) virus and the six internal protein genes of the cold-adapted (ca) A/Ann Arbor/6/60 ca (AA ca) (H2N2) virus. The reassortant H7N7 NL/03 ca vaccine virus was temperature sensitive and attenuated in mice, ferrets, and African green monkeys (AGMs). Intranasal (i.n.) administration of a single dose of the H7N7 NL/03 ca vaccine virus fully protected mice from lethal challenge with homologous and heterologous H7 viruses from Eurasian and North American lineages. Two doses of the H7N7 NL/03 ca vaccine induced neutralizing antibodies in serum and provided complete protection from pulmonary replication of homologous and heterologous wild-type H7 challenge viruses in mice and ferrets. One dose of the H7N7 NL/03 ca vaccine elicited an antibody response in one of three AGMs that was completely protected from pulmonary replication of the homologous wild-type H7 challenge virus. The contribution of CD8<sup>+</sup>
 and/or CD4<sup>+</sup>
 T cells to the vaccine-induced protection of mice was evaluated by T-cell depletion; T lymphocytes were not essential for the vaccine-induced protection from lethal challenge with H7 wt viruses. Additionally, passively transferred neutralizing antibody induced by the H7N7 NL/03 ca virus protected mice from lethality following challenge with H7 wt viruses. The safety, immunogenicity, and efficacy of the H7N7 NL/03 ca vaccine virus in mice, ferrets, and AGMs support the evaluation of this vaccine virus in phase I clinical trials.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Min, Ji Young" sort="Min, Ji Young" uniqKey="Min J" first="Ji-Young" last="Min">Ji-Young Min</name>
</noRegion>
<name sortKey="Bin Lu" sort="Bin Lu" uniqKey="Bin Lu" last="Bin Lu">BIN LU</name>
<name sortKey="Hong Jin" sort="Hong Jin" uniqKey="Hong Jin" last="Hong Jin">HONG JIN</name>
<name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name>
<name sortKey="Matsuoka, Yumiko" sort="Matsuoka, Yumiko" uniqKey="Matsuoka Y" first="Yumiko" last="Matsuoka">Yumiko Matsuoka</name>
<name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<name sortKey="Swayne, David" sort="Swayne, David" uniqKey="Swayne D" first="David" last="Swayne">David Swayne</name>
<name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F93 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000F93 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:10-0511493
   |texte=   A Live Attenuated H7N7 Candidate Vaccine Virus Induces Neutralizing Antibody That Confers Protection from Challenge in Mice, Ferrets, and Monkeys
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration H2N2

A Live Attenuated H7N7 Candidate Vaccine Virus Induces Neutralizing Antibody That Confers Protection from Challenge in Mice, Ferrets, and Monkeys

A Live Attenuated H7N7 Candidate Vaccine Virus Induces Neutralizing Antibody That Confers Protection from Challenge in Mice, Ferrets, and Monkeys

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri